Ion Channel Function and Cross-Species Determinants in Viral Assembly of Nonprimate Hepacivirus p7

Acute and chronic infections with nonprimate hepacivirus in young horses

The recently discovered nonprimate hepacivirus (NPHV) naturally infects horses and is the closest known homolog of hepatitis C virus to date. Within a follow-up study acute field infections were monitored in four young Thoroughbred horses until the ages of 12-13 months. Serum samples were analyzed for the presence of NPHV RNA and anti-NPHV NS3 antibodies and liver specific parameters were evalu...

Ion Channel Assembly: Creating Structures that Function

With advances in recombinant DNA, structural, and electrophysiological techniques, much progress has been made in understanding the structure and, in particular , the function of ion channels. Less progress has been made in resolving the cell biological events that guide the assembly and trafficking of these proteins and that have a major impact on both structure and function. The assembly of a...

Targeting the Hepatitis C virus ion channel p7 for anti-viral therapy

Introduction Hepatitis C virus (HCV) currently infects over 3 % of the world population and is the major indicator for liver transplant surgery in the west. Acute infection is usually asymptomatic but leads to persistence in the majority of cases causing chronic liver disease. Treatment of the virus is currently limited to the use of type 1 interferon either alone, or in combination with the gu...

‏‎interpersonal function of language in subtitling

‏‎translation as a comunicative process is always said to be associated with various aspects of meaning loss or gain. subtitling as a mode of translating, due to special discoursal and textual conditions imposed upon it, is believed to be an obvious case of this loss or gain. presenting the spoken sound track of a film in writing and synchronizing the perception of this text by the viewers with...

Long alkylchain iminosugars block the HCV p7 ion channel.